Home to the storied Mississippi River and the Ozark Mountains, Missouri has a special place in America’s history. The state acted as a conduit for settlers expanding the United States westward, who founded the Pony Express, the Santa Fe Trail and other migratory routes in Missouri. Economically Missouri is a diverse region; major industries in the state include beer and wine brewing, aerospace, food processing, transportation and electrical equipment manufacturing. In this research brief we will review some of the state-level grant and support programs available for small businesses based in the state.